Lilly starts construction of $3.5bn obesity-medicine plant in Pennsylvania

Key highlights
  • The facility is expected to create 850 permanent jobs and about 2,000 construction jobs.
  • The Fogelsville site is expected to be operational by 2031.
  • It is one of four injectable-medicine and device sites among 10 U.S. manufacturing sites Lilly has announced since 2020.
  • Retatrutide is an investigational GIP, GLP-1 and glucagon triple-receptor agonist being studied in Phase 3 trials.

Facility and production

Lilly has broken ground on a manufacturing facility in Fogelsville, Pennsylvania, to expand U.S. capacity for injectable medicines, including the investigational obesity treatment retatrutide. The site is expected to be operational by 2031 and is one of four injectable-medicine and device facilities among 10 U.S. sites announced by Lilly since 2020.

The company expects the project to create 850 jobs, including engineering, science, operations and laboratory roles, and about 2,000 construction jobs. The site is planned to use machine learning, artificial intelligence, digitally integrated systems, data analytics and automation. Lilly is targeting LEED Gold certification.

Retatrutide

Retatrutide is a single-molecule agonist of the GIP, GLP-1 and glucagon receptors. Lilly is evaluating it in Phase 3 trials for obesity and overweight with related health conditions, as well as several other indications. It is investigational and cannot be legally sold or marketed for human use.

Source: Lilly

chemXplore Weekly

The week’s project milestones and project news from the chemical industry, free every Wednesday.

Free. One email a week. Unsubscribe any time. See our Privacy Policy.

Related articles

5 November 2026
Lilly showcases retatrutide, Taltz (ixekizumab) and Zepbound (tirzepatide) data at ACR Convergence 2026

Phase 3 TRIUMPH trials showed retatrutide cut knee pain by up to 75.8% with some patients pain‑free; TOGETHER‑PsA found ixekizumab plus tirzepatide raised ACR50 to 43.7% at 52 weeks.

28 October 2026
Lilly’s retatrutide outperforms Ozempic 2 mg in A1C and weight loss in Phase 3 head‑to‑head

At 80 weeks retatrutide lowered A1C by 2.2% and reduced weight ~20% (44–47 lbs) versus Ozempic 2 mg’s 1.8% A1C reduction and 9.4% (~21 lbs) weight loss.

29 September 2026
Lilly retatrutide shows large weight loss and A1C reductions in TRIUMPH-2

Triple agonist produced up to 20.8% weight loss and up to 1.6% A1C reduction at 80 weeks in adults with type 2 diabetes and obesity.

23 July 2026
Lilly's retatrutide shows large weight and A1C reductions in Phase 3 TRIUMPH‑2 and TRIUMPH‑3

First‑in‑class triple agonist delivered large 80‑week weight losses and meaningful A1C and cardiometabolic improvements in difficult‑to‑treat obesity populations.

30 September 2026
Lilly's EloraTZP (eloralintide + tirzepatide) outperforms tirzepatide 15 mg in Phase 2b obesity and T2D trial

Combination achieved up to 23.3% weight loss (54.1 lbs) and 2.9% A1C reduction versus 14.8% (34.4 lbs) and 2.4% with tirzepatide; Phase 3 to start Q4 2026.