DuPont launches AmberChrom™ SIL silica gel for peptide purification
- DuPont launched AmberChrom™ SIL, a reverse-phase silica gel for purification of peptide therapeutics including GLP‑1 receptor agonists.
- AmberChrom™ SIL is offered in C8 and C18 chemistries to address demanding peptide separations with high resolution and stability.
- The media is designed for use across purification stages, from crude peptide cleanup through final polishing.
- Application studies show competitive purity and yield performance and stability under conditions commonly used for peptide purification.
Product overview
DuPont introduced AmberChrom™ SIL, a reverse-phase silica gel formulated to support purification and manufacture of peptide therapeutics, including GLP‑1 receptor agonists. The media is supplied in C8 and C18 chemistries to address a range of peptide separation needs.
Applications
AmberChrom™ SIL is positioned for use across multiple purification stages — from removal of impurities in crude peptide mixtures to final high‑purity polishing steps. Reverse‑phase silica is described as a core technology for removing impurities prior to downstream polishing.
Workflow integration
The product is designed to be integrated with DuPont’s AmberChrom™ polymeric resins (XT, TQ1 and CG), enabling combined silica and polymer workflows to optimise purity, yield and recovery while simplifying purification strategy development.
Performance and scale-up
Application studies cited by DuPont indicate AmberChrom™ SIL delivers competitive purity and yield and maintains stability under common peptide purification conditions, supporting both process development and manufacturing scale‑up.
Source: DuPont