Gearbox Biosciences (OÜ Gearbox Biosciences) is an Estonian biotechnology company specializing in tools and processes for microbial biomanufacturing, with a core focus on plasmid DNA (pDNA) production. The company develops genetic systems, host strains, and workflow solutions aimed at improving the scalability, efficiency, and regulatory suitability of pDNA manufacturing for applications in gene and cell therapies, vaccines, and research.
Its technology portfolio includes antibiotic-free approaches to plasmid maintenance and other selection strategies intended to streamline upstream fermentation and downstream purification, reduce production costs, and address antibiotic-resistance concerns. Gearbox Biosciences collaborates with biopharmaceutical developers and contract manufacturers to integrate its solutions into GMP-aligned production platforms.
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The collaboration aims to enhance plasmid DNA production with antibiotic-free methods, improving scalability, efficiency, and cost-effectiveness for advanced therapies.
